Dr. Gregory Michael, an obstetrician in personal follow at Mount Sinai Medical Middle in Miami Seashore, acquired a primary dose of the Pfizer/BioNTech experimental mRNA COVID-19 vaccine on December 18, 2020 and died 16 days later of a cerebral hemorrhage (stroke).1
Inside three days of taking the shot, he developed signs of a extreme autoimmune bleeding dysfunction, idiopathic thrombocytopenic purpura (ITP), typically referred to as immune thrombocytopenia.2 In line with his spouse, the 56-year outdated OB/GYN doctor was wholesome when he acquired the COVID-19 vaccine and commenced exhibiting signs of bleeding underneath the pores and skin inside 72 hours.
He was hospitalized within the intensive care unit however not one of the remedies had been capable of cease the interior bleeding.3 The case is being investigated by the Miami-Dade County health worker, which is working with the U.S. Facilities for Illness Management and Prevention and Florida Division of Well being.4
In accordance to the Miami Herald, as of January 7, 2021, a Pfizer official stated Michael died of a “extremely uncommon scientific case of extreme thrombocytopenia, a situation that decreases the physique’s means to clot blood and cease inner bleeding.”
The Pfizer spokesman added, “We’re actively investigating this case however we don’t consider at the moment that there’s any direct connection to the vaccine.”5 A CBS report quoted the Pfizer spokesman as saying:6
“There have been no associated security indicators recognized in our scientific trials, the post-marketing expertise thus far or with the mRNA vaccine platform. Up to now thousands and thousands of individuals have been vaccinated and we’re carefully monitoring all adversarial occasions in people receiving our vaccine.
It is very important notice that severe adversarial occasions, together with deaths which can be unrelated to the vaccine are sadly more likely to happen at an identical fee as they’d within the basic inhabitants.”
Spouse: Gregory Michael ‘Liked by Everybody within the Neighborhood’
The well-known and standard obstetrician, who was a Miami native, Michael had operated a personal OB/GYN follow in Miami Seashore for 12 years and in addition labored as a scientific teacher and college member for the doctor assistant program at Barry College and Miami Dade School. He was the daddy of a 15-year-old daughter.
His spouse, Heidi Neckelmann, made a heartfelt put up on-line7 calling her husband “the love of my life” who was “liked by everybody within the neighborhood, delivered a whole bunch of wholesome infants and labored tirelessly via the pandemic.” When informing her associates about his loss of life, she requested them to share her put up so the general public is extra conscious that the COVID-19 vaccine shouldn’t be risk-free. She stated:
“He was a professional vaccine advocate and that is why he received it himself. I consider that folks must be conscious that aspect results can occur, that it’s not good for everybody and, on this case, destroyed a stupendous life, an ideal household, and has affected so many individuals in the neighborhood. Don’t let his loss of life be in useless, please save extra lives by making this data information.”
CDC: ‘Potential Advantages’ of COVID Vaccines ‘Outweigh Dangers’
A CBS report quoted Dr. Nancy Messonnier, director of the CDC’s Nationwide Middle for Immunization and Respiratory Illnesses, as saying, “The identified and potential advantages of the present COVID-19 vaccines outweigh the identified and potential dangers of getting COVID-19. That doesn’t imply, nevertheless, that we couldn’t see potential severe well being occasions sooner or later.”
Reportedly, CDC officers advised reporters they’d not seen any severe reactions past 29 instances of extreme allergic reactions — or about 11 instances of anaphylaxis per 1 million doses of COVID-19 vaccinations administered.8
ITP Brought on by Autoantibody-Mediated Platelet Destruction
Idiopathic or immune thrombocytopenic purpura (ITP) is a fancy autoimmune dysfunction brought on by autoantibody-mediated destruction of platelets, that are cells in the blood that assist cease bleeding.9 Mainly, the immune system malfunctions and produces antibodies that assault the physique’s platelets. In some instances, T-cells (a kind of white blood cell) will instantly assault and destroy the platelets.10
ITP has been reported to develop after infections, together with SARS-CoV-2 an infection;11 reactions to prescribed drugs and over-the-counter drugs,12 being pregnant, publicity to chemical toxins,13 vaccination,14 or as a complication of autoimmune issues like rheumatoid arthritis and lupus, however all of the causes of ITP are nonetheless not identified.
A regular platelet rely is between 150,000 to 450,000 platelets and ITP can drive the platelet rely right down to lower than 10,000 platelets, which causes vital inner bleeding.
Signs of ITP could start with the looks of tiny purple dots underneath the pores and skin, which point out very small bleeds, and progress to purple blotches and bruises on massive areas of the pores and skin, in addition to nosebleeds, bleeding within the mouth and across the gums, and blood within the vomit, urine or stool, which point out a lot extra severe inner bleeding.
The most harmful complication of ITP is bleeding within the mind inflicting a cerebral hemorrhage and catastrophic mind injury or loss of life.15 Remedies that attempt to sluggish or cease the destruction of platelets throughout ITP are restricted and embrace intravenous gamma globulin (IVGG) and platelet infusions, steroids and several other different drugs, or elimination of the spleen.16
ITP in youngsters, which happens in 1 in 20,000 youngsters, might be extra simply reversed than ITP in adults, which happens in about 1 in 15,000 adults within the U.S. and is extra widespread in girls and people over age 60.17,18 Nearly all of youngsters recuperate from acute ITP however roughly 30% of adults have persistent illness after creating ITP and 5% die from hemorrhage.19
ITP Reported After and Causally Associated to Vaccinations
In 1991, an Institute of Drugs committee on the Nationwide Academy of Sciences acknowledged in its report titled “Hostile Results of Pertussis and Rubella Vaccines” that there have been too few scientific research revealed within the medical literature investigating ITP following entire cell pertussis (DPT) vaccination or rubella (MMR) vaccination for the committee to find out whether or not or not DPT or MMR vaccine causes ITP in youngsters.20,21
Nonetheless, studies continued to be revealed within the medical literature.22 In 2001, a examine was revealed in Archives of Illness in Childhood confirming a causal affiliation between measles-mumps-rubella vaccine and ITP.
Research authors stated, “Absolutely the danger inside six weeks of immunization was 1 in 22,300 doses, with two of each three instances occurring within the six-week post-immunization interval being brought on by MMR.”23 The CDC’s web site at the moment states:24
“Immune thrombocytopenic purpura (ITP) is a dysfunction that decreases the physique’s means to cease bleeding. It may possibly occur after each pure measles an infection in addition to after getting the MMR vaccine.
Nonetheless, it’s normally not life threatening. Remedy could embrace blood transfusion and drugs. The danger of ITP has been proven to be elevated within the six weeks following an MMR vaccination, with one examine estimating 1 case per 40,000 vaccinated youngsters.”
Throughout the previous decade, there have been numerous revealed research from the U.S. and different nations that ITP develops after receipt of vaccines, together with HPV25 and influenza vaccines,26,27 with authors calling for extra analysis into the affiliation between vaccination and ITP.28,29,30 One group of researchers trying on the relationship between ITP and vaccinations stated in 2014:31
“Vaccines could induce ITP by a number of mechanisms. Vaccine-associated autoimmunity could stem not solely from the antigen-mediated responses but additionally from different constituents of the vaccine, corresponding to yeast proteins, adjuvants, and preservative diluents. The probably is thru virally induced molecular mimicry …
The autoantibodies speculation shouldn’t be adequate to clarify all ITP instances: Within the anti-platelet antibody-negative instances, a complementary mechanism based mostly on T cell immune-mediated mechanism has been urged. Specifically, T cell subsets appear dysregulated with an elevated manufacturing of pro-inflammatory cytokines, as IFN-y and TNF, and chemokines, as CXCL10.”
An editorial within the October 2020 Worldwide Journal of Infectious Illnesses titled “ITP Following Vaccination” identified that “the time period ‘mosaic of autoimmunity’ signifies that immune mediated issues can contain completely different sources, together with genetics, environmental components and hormonal or immune defects.”32
The editors famous that vaccination is among the “environmental triggers” that has been described within the medical literature in affiliation with ITP. The journal editors, who known as for extra analysis into the vaccination-ITP affiliation, acknowledged:33,34
“Whatever the mechanism via which synthetic immunization causes ITP, it has been reported following vaccinations towards numerous infectious brokers, particularly measles-mumps-rubella (MMR), but additionally Haemophilus influenza [HIB], hepatitis B (HBV), human papilloma virus (HPV), varicella zoster [chickenpox], diphtheria-tetanus acellular pertussis (DTap), polio and pneumococcus vaccines.
A French examine that evaluated drug-induced ITP discovered that round 45% of the instances had been post-vaccinal.”
FDA: Moderna COVID-19 Vaccine Trial Had ITP Case
Pfizer didn’t report a case of ITP occurring in scientific trials of its experimental COVID-19 mRNA vaccine, which was the vaccine that Michael acquired.35
Nonetheless, in a briefing doc ready for the December 17, 2020, Vaccines and Associated Organic Merchandise Advisory Committee assembly, the place members of the committee voted on granting Moderna an Emergency Use Authorization (EUA) to distribute its mRNA COVID-19 vaccine within the U.S., the FDA did notice a case of ITP in a 72-year-old scientific trial participant who was hospitalized with thrombocytopenia and obstructive kidney stone illness after receiving the experimental vaccine and died of multiorgan failure.
In discussing deaths that occurred within the Moderna COVID-19 vaccine scientific trials, the FDA acknowledged:36
“One case was a 72-year-old vaccine recipient with Crohn’s illness and quick bowel syndrome who was hospitalized for thrombocytopenia and acute kidney failure as a result of obstructive nephrolithiasis [kidney stone] 40 days after dose 2 and developed issues leading to multiorgan failure and loss of life.”